Ageing accelerates around age 50 ― some organs faster than others

Study scope and interpretation

• Several commenters note the study’s very small sample (76 people, 14–68) and limited age range, so they’re cautious about strong conclusions or precise “cutoff” ages.
• Others point out that the paper focuses on biomolecular changes in internal organs, which people usually don’t directly “feel,” so it explains biology more than subjective experience.

Programmed vs damage-based aging

• One thread argues aging is at least partly a scheduled genetic program, possibly shaped by group-level selection; menopause is cited as a clear programmed shutdown.
• Counterarguments stress aging as cumulative damage plus imperfect repair; similar aging patterns across people and species can arise from the same machinery wearing out, not a lifespan “kill switch.”
• Debate covers why we don’t see humans living 5× longer if aging were either purely random damage or a bug-prone program; combinatorics and multiple redundant systems are invoked.
• Telomeres, cancer risk, germline vs somatic cells, and evolutionary trade-offs are discussed without clear consensus.

Historical lifespan and evolution

• Multiple commenters correct the “people used to die at 40” trope, emphasizing that low averages were largely due to child and maternal mortality; many adults historically reached 60–80.
• This is used to argue that whatever “program” exists likely always included older ages.

Nonlinear aging and personal timelines

• Many report clear “steps” rather than smooth decline: late 30s, early/mid 40s, ~50, and 60s are common inflection points.
• Another recent study finding peaks at 44 and 60 is referenced and widely seen as matching lived experience.

Lifestyle, exercise, and reversibility

• Numerous accounts of people in their 40s–60s starting or intensifying strength training, cardio, and diet control and feeling dramatically younger, sometimes in best-ever shape.
• Others describe chronic injuries, loss of explosive power, and slower recovery even with training.
• Disagreement over how much late-life lifestyle change can “catch up” to decades of neglect; some say you can’t compress decades of missed exercise, others argue you can get close to your personal limit in a few consistent years.

Diet, drugs, and interventions

• Suggestions range from probiotics and collagen to keto/carnivore, low-carb, and cutting sugar, alcohol, and caffeine; there is debate about plant-heavy vs meat-heavy keto.
• Some describe extensive use of TRT, GLP‑1 agonists, and peptides, reporting major gains in energy, body composition, and sleep, while acknowledging long-term dependence and medical monitoring.

Psychology, agency, and acceptance

• Several comments emphasize that while aging and death are inevitable, choices around movement, diet, sleep, and mindset dramatically affect how old one feels.
• Others grapple with fear of missing future technological progress and with depression-like exhaustion in their 30s, with replies pointing to possible sleep, diet, thyroid, vitamin D, or mental-health issues.
• A recurring theme: maintain activity and curiosity; don’t let social expectations about age unduly limit what you attempt.